• Lluís Orozco Delclós,
• Robert Soler Rich,
• Rafael Arriaza Loureda,
• Alonso Moreno García &
• Enrique Gómez Barrena 

Journal of Translational Medicine volume 22, Article number: 493 (2024) Cite this article

DOI: 10.1186/s12967-024-05280-x

Abstract

Autologous bone grafting is the standard treatment for the surgical management of atrophic nonunion of long bones. Other solutions, such as bone marrow mesenchymal stem cells (BM-MSC) combined with phospho-calcium material, have also been used. Here we evaluate the safety and early efficacy of a novel procedure using autologous or allogenic adipose tissue mesenchymal stromal cells (AT-MSC) seeded in a patented tricalcium phosphate-based biomaterial for the treatment of bone regeneration in cases of atrophic nonunion.