Presentación    
CLINICAL PHARMACOLOGY
Composition and lines of research
Projects
Clinical trials
Publications
Doctoral theses
Patents and trademarks
Publications
Ongoing publications
Publications 2014
DOCUMENT I.F. CUARTILE
Rivera-Núñez, M. A.; Borobia, A. M.; García-Erce, J. A.; de Gracia, M. M.; Pérez-Perilla, P.; Quintana-Díaz, M. Acute complications and outcomes of acute head injury in adult patients with haemophilia. EUROPEAN JOURNAL OF EMERGENCY MEDICINE. 2014; 21(5): 380-383. Artículo. 1,583 Q2
Estebánez, M.; Stella-Ascariz, N.; Mingorance, J.; Pérez-Valero, I.; González-Baeza, A.; Bayón, C.; Lakatos, B.; Borobia, A.; Arnalich, F.; Arribas, J. R. A comparative study of neurocognitively impaired patients receiving protease inhibitor monotherapy or triple-drug antiretroviral therapy. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES. 2014; 67(4): 419-423. Artículo. 4,556 Q1
Arab-Alameddine, M.; Lubomirov, R.; Fayet-Mello, A.; Aouri, M.; Rotger, M.; Buclin, T.; Widmer, N.; Gatri, M.; Ledergerber, B.; Rentsch, K.; Cavassini, M.; Panchaud, A.; Guidi, M.; Telenti, A.; Decosterd, L. A.; Csajka, C. Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2014; 69(9): 2489-2498. Artículo. 5,313 D1
Cabañas, R.; Calderón, O.; Ramírez, E.; Fiandor, A.; Prior, N.; Caballero, T.; Herranz, P.; Bobolea, I.; López-Serrano, M. C.; Quirce, S.; Bellón, T. Piperacillin-induced DRESS: distinguishing features observed in a clinical and allergy study of 8 patients. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY. 2014; 24(6): 425-430. Artículo. 2,596 Q3
Carcas-Sansuán, A. J.; Espinosa-Román, L.; Almeida-Paulo, G. N.;
Alonso-Melgar, A.; García-Meseguer, C.; Fernández-Camblor, C.; Medrano, N.; Ramírez, E. Conversion from prograf to advagraf in stable paediatric renal transplant patients and 1-year follow-up. PEDIATRIC NEPHROLOGY. 2014; 29(1): 117-123. Artículo.		 2,856 Q1
Ramírez, E.; Romero-Garrido, J. A.; López-Granados, E.; Borobia, A. M.; Pérez, T.; Medrano, N.; Rueda, C.; Tong, H. Y.; Herrero, A.; Frías, J. Symptomatic thromboembolic events in patients treated with intravenous-immunoglobulins: results from a retrospective cohort study.
THROMBOSIS RESEARCH. 2014; 133(6): 1045-4051. Artículo.		 2,447 Q3
Almeida-Paulo, G. N.; Lubomirov, R.; Alonso-Sánchez, N. L.; Espinosa-Román, L.; Camblor, C. F.; Díaz, C.; Bartola, G. M.; Carcas-Sansuán, A.J. Limited sampling strategies for tacrolimus exposure (AUC(0-24)) predictionafter Prograf (R) and Advagraf (R) administration in children and adolescents with liver or kidney transplants. TRANSPLANT INTERNATIONAL. 2014; 27(9): 939-948. Artículo. 2,599 Q2
Díaz, M. Q.; Borobia, A. M.; Zegarra, C.; Núñez, M. A.; Virto, A. M.; García-Erce, J. A. Experience using prothrombin complex concentrate in a hospital emergency department. EMERGENCIAS. 2014; 26(4): 303-306. Material Editorial. 2,895 Q1
Ramírez, E.; Tong, H. Y.; Fiandor, A.; Martín-Hervás, C.; Rivero, D.; Onate, M.; Rueda, C.; Cabañas, R.; Moro, M.; Tapia, M.; Fernández, A.; Morón, S.; Herrero, A.; Garzón, G.; Quirce, S.; Frías, J. Hypersensitivity reactions to contrast media injections: a nested case-control study. ANNALS OF ALLERGY, ASTHMA & IMMUNOLOGY. 2014; 113(4): 488-489. Carta. 2,599 Q2
González-Suárez, I.; Aguilar-Amat, M. J.; Trigueros, M.; Borobia, A. M.; Cruz, A.; Arpa, J. Leukoencephalopathy due to oral methotrexate. CEREBELLUM. 2014; 13(1): 178-183. Revisión. 2,717 Q3
Publications 2009 - 2013
YEAR NAME I.F. CUARTILE
2013 Ramírez, E.; Cabañas, R.; Laserna, L. S.; Fiandor, A.; Tong, H.; Prior, N.; Calderón, O.; Medrano, N.; Bobolea, I.; Frías, J.; Quirce, S. Proton pump inhibitors are associated with hypersensitivity reactions to drugs in hospitalized patients: a nested case-control in a retrospective cohort study. CLINICAL AND EXPERIMENTAL ALLERGY. 2013; 43(3): 344-352. Artículo. 4,324 Q1
2013 López-Parra, A. M.; Borobia, A. M.; Baeza, C.; Arroyo-Pardo, E.; Carcas, A. J. A multiplex assay to detect variations in the CYP2C9, VKORC1, CYP4F2 and APOE genes involved in acenocoumarol metabolism. CLINICAL BIOCHEMISTRY. 2013; 46(1-2): 167-169. Artículo. 2,229 Q2
2013 Ramírez, E.; Abraira, V.; Guerra, P.; Borobia, A. M.; Duque, B.; López, J. L.; Mosquera, B.; Lubomirov, R.; Carcas, A. J.; Frías, J. A preliminary model to avoid the overestimation of sample size in bioequivalence studies. DRUG RESEARCH. 2013; 63(2): 98-103. Artículo. No Indexado No Indexado
2013 Muñoz, R.; Borobia, A. M.; Quintana, M.; Martínez-Virto, A. M.;
Frías, J.; Carcas, A. J. Development and validation of a poisoning
surveillance program with automatic case detection in a tertiary care hospital (SAT-HULP). EMERGENCIAS. 2013; 25(6): 423-429. Artículo.		 2,583 Q1
2013 Ramírez, E.; Rossignoli, T.; Campos, A. J.; Muñoz, R.; Zegarra, C.; Tong, H.; Medrano, N.; Borobia, A. M.; Carcas, AJ.; Frías, J. Drug-induced life-threatening potassium disturbances detected by a pharmacovigilance program from laboratory signals. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2013; 69(1): 97-110. Artículo. 2,697 Q2
2013 Ramírez, E.; Gómez-Gil, R.; Borobia, A. M.; Moreno, F.; Zegarra,
C.; Muñoz, R.; Reutero, Z.; de Montreuil, C.; González, D.; Hernández, S.; Herrero, A.; Gutiérrez, A.; Frías, J. Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2013; 41(2): 174-178. Artículo.		 4,259 Q1
2013 Ramírez, E.; Gómez-Gil, R.; Borobia, A. M.; Moreno, F.; Zegarra, C.; Muñoz, R.; Reutero, Z.; de Montreuil, C.; González, D.; Hernández, S.; Herrero, A.; Gutiérrez, A.; Frías, J. Improving linezolid use decreases the incidence of resistance among Gram-positive microorganisms. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2013; 41(2): 174-178. Artículo. 4,259 Q1
2013 Carcas-Sanjuán, A. J.; Hierro, L.; Almeida-Paulo, G. N.; Frauca, E.; Tong, H. Y.; Díaz, C.; Piñana, E.; Frías-Iniesta, J.; Jara, P. Conversion from prograf to advagraf in adolescents with stable liver transplants: comparative pharmacokinetics and 1-year follow-up. LIVER TRANSPLANTATION. 2013; 19(10): 1151-1158. Artículo. 3,793 D1
2013 Dobrinas, M.; Crettol, S.; Oneda, B.; Lahyani, R.; Rotger, M.; Choong, E.; Lubomirov, R.; Csajka, C.; Eap, C. B. Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study. PHARMACOGENETICS AND GENOMICS. 2013; 23(2): 84-93. Artículo. 3,45 Q1
2013 López-Rodríguez, R.; Cabaleiro, T.; Ochoa, D.; Román, M.; Borobia, A. M.; Carcas, A. J.; Ayuso, C.; Novalbos, J.; Abad-Santos, F. Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers. PHARMACOGENOMICS. 2013; 14(10): 1203-1214. Artículo. 3,425 Q1
2013 Ramírez, E.; Jiménez, C.; Borobia, A. M.; Tong, H. Y.; Medrano,
N.; Krauel-Bidwell, L.; Carcas, A. J.; Selgas, R.; Frías, J. Vancomycin-
induced acute kidney injury detected by a prospective pharmacovigilance program from laboratory signals. THERAPEUTIC DRUG MONITORING. 2013; 35(3): 360-366. Artículo.		 1,926 Q2
2013 Díaz, M. Q.; Borobia, A. M.; Núñez, M. A. R.; Virto, A. M. M.; Fabra, S.; Casado, M. S.; García-Erce, J. A.; Samama, C. M. Use of prothrombin complex concentrates for urgent reversal of dabigatran in the Emergency Department. HAEMATOLOGICA. 2013; 98(11): E143-E144. Carta. 5,868 D1
2012 Arab-Alameddine, M.; Fayet-Mello, A.; Lubomirov, R.; Neely, M.; di Iulio, J.; Owen, A.; Boffito, M.; Cavassini, M.; Gunthard, H. F.; Rentsch, K.; Buclin, T.; Aouri, M.; Telenti, A.; Decosterd, LA.; Rotger, M.; Csajka, C. Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals. ANTIMICROBIAL AGENTS AND HEMOTHERAPY. 2012; 56(6): 2959-2966. Article.  4,565 Q1
2012 Borobia, A. M.; Lubomirov, R.; Ramírez, E.; Lorenzo, A.; Campos,
A.; Muñoz-Romo, R.; Fernández-Capitán, C.; Frías, J.; Carcas, A. J. An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in spanish patients with thromboembolic disease. PLOS ONE. 2012; 7(7): e41360. Article.		  3,73 Q1
2012 Carcas, A. J.; Borobia, A. M.; Velasco, M.; Abad-Santos, F.; Díaz, M. Q.; Fernández-Capitán, C.; Ruiz-Giménez, N.; Madridano, O.; Sillero, P. L. Efficiency and effectiveness of the use of  an acenocoumarol pharmacogenetic dosing algorithm versus usual care in patients with venous thromboembolic disease initiating oral anticoagulation: study protocol for a randomized controlled trial. TRIALS. 2012; 13: 239. Article.  2,206  Q3
2012 Díaz, M. Q.; Borobia, A. M.; Cachafeiro, S. P.; Rodríguez, C.; Erce, J. A. G. Cost-effectiveness of using prothrombin complex concentrate to prevent complications related to overdoses of anticoagulants in the emergency department. EMERGENCIAS. 2012; 24(2): 113-120. Article.  2,578  Q1
2012 Ramírez, E.; García-Rodríguez, J.; Borobia, A. M.; Ortega, J.M.; Lei, S.; Barrios-Fernández, A.; Sánchez, M.; Carcas, A.J.; Herrero, A.; de la Puente, J. M.; Frías, J. Use of antifungal agents in pediatric and adult high-risk areas. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 2012; 31(3): 337-347. Article.  3,024 Q2
2012 Álvarez, C.; Gómez, E.; Simón, M.; Govantes, C.; Guerra, P.; Frías, J.; García-Arieta, A. Differences in lercanidipine systemic exposure when administered according to labelling: in fasting state and 15 minutes before food intake. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012; 68(7): 1043-1047. Article.  2,741 Q2
2012 García-Erce, J. A.; Borobia, A. M.; Fabra, S.; Díaz, M. Q. Blood transfusion in the emergency department. EMERGENCIAS. 2012; 24(5): 417-417. Letter. 2,578 Q1
2011 Frías, J.; Pascual, J.; Lahuerta, J.; Gracia, D.; Dal-Re, R. Ethical problems arising from the use of placebo in clinical trials with drugs for migraine. Their analysis by the moral deliberation method. NEUROLOGIA. 2011; 26(2): 92-99. Article.  0,79 Q4
2010 Oliver, P.; Lubomirov, R,; Carcas, A, Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers. CLINICAL CHEMISTRY AND LABORATORY MEDICINE. 2010; 48(5): 635-639. Article.  2,069 Q2
2010 Fudio, S.; Borobia, A. M.; Piñana, E.; Ramírez, E.; Tabares, B.; Guerra, P.; Carcas, A.; Frías, J. Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram. EUROPEAN JOURNAL OF PHARMACOLOGY. 2010; 626(02- Mar): 200-204. Article. 2,737 Q2
2010 Piñana, E.; Lei, S. H.; Merino, R.; Melgosa, M.; De La Vega, R.; Gonzales-Obeso, E.; Ramírez, E.; Borobia, A.; Carcas, A. DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpevirus 6 in an 11-year-old caucasian boy. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS. 2010; 35(3): 365-370. Article. 1,649 Q3
2010 Ramírez, E.; Carcas, A. J.; Borobia, A. M.; Lei, S. H.; Piñana, E.; Fudio, S.; Frías, J. A. Pharmacovigilance Program From Laboratory Signals for the Detection and Reporting of Serious Adverse Drug Reactions in Hospitalized Patients. CLINICAL PHARMACOLOGY & THERAPEUTICS. 2010;  87(1): 74-86. Article.  6,378 Q1
2010 Ramírez, E.; Lei, S. H.; Borobia, A. M.; Piñana, E.; Fudio, S.; Muñoz, R.; Campos, A.; Carcas, A. J.; Frías J. Overuse of PPIs in patients at admission, during treatment, and at discharge in a tertiary Spanish hospital.    CURRENT CLINICAL PHARMACOLOGY. 2010; 5(4): 288-297. Article. N/A N/A
2010 Ramírez, E; Laosa, O; Guerra, P; Duque, B; Mosquera, B; Borobia, AM; Lei, SH; Carcas, AJ; Frias, J. Acceptability and characteristics of 124 human bioequivalence studies with active substances classified according to the Biopharmaceutic Classification System. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2010; 70(5): 694-702. Article. 3,063 Q2
2009 Perez-Olmeda, M; Garcia-Perez, J; Mateos, E; Spijkers, S; Ayerbe, MC; Carcas, A; Alcami, J. In Vitro Analysis of Synergism and Antagonism of Different Nucleoside/Nucleotide Analogue Combinations on the Inhibition of Human Immunodeficiency Virus Type 1 Replication. JOURNAL OF MEDICAL VIROLOGY. 2009; 81(2): 211-216 2,470
Q3
2009 Borobia, AM; Fudio, S; Sansuan, AJC. Valproate-meropenem co-administration, an example of information shortcomings in relevant drug interactions. MEDICINA CLINICA. 2009; 132(20): 803-804 1,231
Q3
2009 Borobia, AM; Novalbos, J; Guerra-Lopez, P; Lopez-Rodriguez, R; Tabares, B; Rodriguez, V; Abad-Santos, F; Carcas, AJ. Influence of sex and CYP2D6 genotype on mirtazapine disposition, evaluated in Spanish healthy volunteers. PHARMACOLOGICAL RESEARCH. 2009; 59(6): 393-398 3,929
Q1
2009 Borobia, AM; Lopez-Parra, AM; Tabares, B; Ramirez, E; Baeza, C; Arroyo-Pardo, E; Carcas, AJ. CYP2C9 polymorphism in five autochthonous population of the same geographic area (Spanish Pyrenees). PHARMACOLOGICAL RESEARCH. 2009; 59(2): 107-111 3,929
Q1
2009 Borobia, AM; Capitan, CF; Arandia, NI; de Paso, PG; Recio, JV; Bizighescuc, M; Sansuan, AJC. Risk of thromboembolic events and evaluation of the use of venous thromboembolism prophylaxis in hospitalized medical patients and after discharge. REVISTA CLINICA ESPANOLA. 2009; 209(1): 15-20 0,584
Q3
2009 Emma Fernández de Uzquiano*, A. Gil Aguado, P. Lavilla Uriol, J. Frías Iniesta, R. Madero Jarabo and R. Álvarez-Sala Walther.. The Spectrum of Clinical Research with Medications in A Spanish. University Hospital. Review of 1.000 Clinical Trials Evaluated by the Research Ethics Committee. THE OPEN ETHICS JOURNAL. 2009; 3(): 20-27 N/A
N/A
2009 Borobia, AM; Romero, I; Jimenez, C; Gil, F; Ramirez, E; De Gracia, R; Escuin, F; Gonzalez, E; Sansuan, AJC. Trough Tacrolimus Concentrations in the First Week After Kidney Transplantation Are Related to Acute Rejection. THERAPEUTIC DRUG MONITORING. 2009; 31(4): 436-442 2,429
Q1