Presentación
LYMPHOCYTE PATHOPHYSIOLOGY IN IMMUNODECFICIENCIES

fisiopatologialinfocitaria@idipaz.es
Composition
Name
Composition
Institution
Eduardo López Granados
Coordinador de Inmunología
Hospital Universitario La Paz
Francisco Javier Alves Ferreira
Facultativo Especialista de Área en Anatomía Patológica
Hospital Universitario La Paz
Luz Yadira Bravo Gallego
Facultativo Especialista de Área en Inmunología
Hospital Universitario La Paz
María Coronel Díaz
Técnico de Laboratorio
Hospital Universitario La Paz
Lucía del Pino Molina
Investigadora Postdoctoral
Hospital Universitario La Paz
Carla Cecilia Gianellli
Facultativo Especialista de Área en Inmunología
Hospital Universitario La Paz
Diego Plaza López de Sabando
Facultativo Especialista de Área en Hemato-Oncología Pediátrica
Hospital Universitario La Paz
Ángel Julián Robles Marhuenda
Facultativo Especialista de Área en Medicina Interna
Hospital Universitario La Paz
Rebeca Rodríguez Pena
Facultativo Especialista de Área en Inmunología
Hospital Universitario La Paz
María Carmen Salcedo Moreno
Técnico de Laboratorio
Hospital Universitario La Paz
Elena Sánchez Zapardiel
Facultativo Especialista de Área en Inmunología
Hospital Universitario La Paz
Ana Sastre Urguelles
Facultativo Especialista de Área en Hemato-Oncología Pediátrica
Hospital Universitario La Paz
Juan Manuel Torres Canizales
Médico Inmunólogo
Hospital Universitario La Paz
Yolanda Soto Serrano
Investigadora Predoctoral
Hospital Universitario La Paz
Strategic Objective
 
Our group attempts to unravel the molecular bases of primary immunodeficiencies (PIDs), a large group of rare conditions (more that 350 types described so far) that virtually affect any cell type of the immune system and increase the risk of infections, autoimmunity and cancer in patients. We take a multidisciplinary clinical, anatomic, genetic, epigenetic and functional approach. By correlating clinical and experimental data, we aim to achieve a better understanding of these rare diseases and lay the grounds for, repurposed or new, more effective treatments.
Taking advantage of the knowledge and resources developed to dissect the immune system in PIDs, we are developing new schemes for immune monitoring of transplanted patients, to better estimate immunosupresion and tolerance, and early detection of severe complications as infections and rejection. Finally, we explore novel approaches for monitoring, and fine tuning 
Research Lines

• To define the anatomical, cellular, molecular and (epi)genetic bases of immunological dysfunction in patients diagnosed with primary immunodeficiency in our clinic.
• The maturation and functional specialization of human B lymphocytes, and its pathophysiology in primary and secondary antibody immunodeficiencies.
• The analysis of the immunological reconstitution after haemopoietic stem cell transplantation, and the discovery and clinical validation of immunological biomarkers for immunosuppression and tolerance in solid organ transplantation.
• The development and clinical implementation of patient-tailored monitoring schemes of immunotherapies in wide clinical use.


 
 

Facultativo Especialista de Área en Inmunología

Facultativo Especialista de Área en Inmunología