Presentación
INNATE IMMUNE RESPONSE

repuestainmuneinnata@idipaz.es
Excellence Group
Composition
Name
Composition
Institution
Eduardo Manuel López-Collazo
Director Científico de IdiPAZ.
Investigador Senior (Contrato Miguel Servet - I2)
Jefe de Laboratorio
Hospital Universitario La Paz
Luis Augusto Aguirre Pérez
Investigador postdoctoral
Hospital Universitario La Paz
Susana Alemany de la Peña
Investigadora Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Jose Avendaño Ortiz
Ayudante de Investigación
Hospital Universitario La Paz
Gloria Cristina Bonel Pérez
Ayudante de investigación
Hospital Universitario La Paz
Lisardo Boscá Gomar
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Ramón Cantero Cid
Facultativo Especialista de Área en Cirugía General y Aparato Digestivo
Hospital Universitario La Paz
Antonio Castrillo Viguera
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Jesús Espada Regalado
Investigador Senior
Instituto Ramón y Cajal de Investigación Sanitaria
Carlos del Fresno Sánchez
Investigador Postdoctoral
(Contrato Miguel Servet Tipo - I)
FIBHULP
Maria Fernández Velasco
Investigadora Senior
(Contrato Miguel Servet T- Tipo I)
Hospital Universitario La Paz
Santiago Gómez Ruiz
Profesor Titular
Universidad Rey Juan Carlos
María Susana Guerra García
Investigadora postdoctoral
Universidad Autónoma de Madrid
Roberto Lozano Rodríguez
Investigador Predoctoral
Hospital Universitario La Paz
Charbel Antonio Maroun Eid 
Facultativo Especialista de Área en Urgencias
Hospital del Norte
Paloma Martín Sanz
Investigadora Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Karla Marina Montalbán Hernéndez
Investigadora Predoctoral
Hospital Universitario La Paz
Rebeca Pérez de Diego
Investigadora Senior (Contrato Ramón y Cajal)
Hospital Universitario La Paz
Sanjiv Prashar
Profesor Titular
Universidad Rey Juan Carlos
Elisa Pulido Lucas
Técnico de laboratorio
Hospital Universitario La Paz
Carolina Rubio Marín
Bioinformática
Hospital Universitario La Paz
Verónica Terrón Arcos
Técnico de Laboratorio
Hospital Universitario La Paz
Strategic Objective
This group focuses on the study of the reprogramming of the innate immune response in the context of inflammatory diseases (e.g., sepsis, cystic fibrosis, acute coronary syndrome, lung cancer) using the description of the various molecular mechanisms that underlie the reprogramming of monocytes/macrophages during refractory states. The innate immune response is activated in various clinical contexts that can be modelled in vitro. The initial reaction of the Innate Immune System is marked by an inflammatory response that is similar in different contexts. However, after the initial response, a “deviation” is produced towards an “alternative” response that may, in many cases, lead to refractory states such as endotoxin and tumour tolerance. These refractory states may have undesirable clinical consequences and their study is the objective of our research.
Research Lines
• Molecular mechanisms of the innate immune system tolerance to tumours in several clinical contexts.
• Molecular mechanisms of endotoxin tolerance in several clinical contexts: respiratory diseases (OSA and cystic fibrosis), acute coronary syndrome, sepsis and septic shock and leukaemias.
• Role of the innate immune system in metastasis.
• Myeloid cell polarization and atherogenesis.
• Role of some mediators of the innate immune system in cardiovascular diseases.