Presentación
INNATE IMMUNE RESPONSE

repuestainmuneinnata@idipaz.es
Excellence Group
Composition
Name
Composition
Institution
Investigador Senior
Contrato Miguel Servet - Tipo II

Jefe de Laboratorio
FIBHULP
Carlos del Fresno Sánchez
Investigador Principal
Contrato Miguel Servet - Tipo I
FIBHULP
Susana Alemany de la Peña
Investigadora Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Gloria Cristina Bonel Pérez
Ayudante de investigación
FIBHULP
Lisardo Boscá Gomar
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Antonio Castrillo Viguera
Investigador Senior
Jefe de Laboratorio
IIB "Alberto Sols"
Luna Ridan Cordeiro Minute
Investigadora Sara Borrel
FIBHULP
Laura Córdoba García
Resposable HUB - Organoides
FIBHULP
Carlos del Fresno Sánchez
Investigador Postdoctoral
(Contrato Miguel Servet Tipo - I)
FIBHULP
Santiago Gómez Ruiz
Profesor Titular
Universidad Rey Juan Carlos
María Susana Guerra García
Investigadora postdoctoral
Universidad Autónoma de Madrid
Kilián Jesús Gutiérrez Viñas
Responsable de laboratorio de Citometría de Flujo
FIBHULP
Roberto Lozano Rodríguez
Investigador Predoctoral
FIBHULP
Cristina de Manuel Gómez
Facultativo Especialista de Área en Pediatría
Hospital Universitario La Paz
Charbel Antonio Maroun Eid 
Facultativo Especialista de Área en Urgencias
Hospital del Norte
Pablo Mata Martínez
Investigador Predoctoral
FIBHULP
Alejandro Pascual Iglesias
Bioinformático
FIBHULP
Rebeca Pérez de Diego
Investigadora Senior (Contrato Ramón y Cajal)
FIBHULP
Sanjiv Prashar
Profesor Titular
Universidad Rey Juan Carlos
Carolina Rubio Marín
Bioinformática
FIBHULP
Verónica Terrón Arcos
Técnico de Laboratorio
FIBHULP
Jaime Valentín Quiroga
Investigador Predoctoral 
FIBHULP
Strategic Objective
This group focuses on the study of the reprogramming of the innate immune response in the context of inflammatory diseases (e.g., sepsis, cystic fibrosis, acute coronary syndrome, lung cancer) using the description of the various molecular mechanisms that underlie the reprogramming of monocytes/macrophages during refractory states. The innate immune response is activated in various clinical contexts that can be modelled in vitro. The initial reaction of the Innate Immune System is marked by an inflammatory response that is similar in different contexts. However, after the initial response, a “deviation” is produced towards an “alternative” response that may, in many cases, lead to refractory states such as endotoxin and tumour tolerance. These refractory states may have undesirable clinical consequences and their study is the objective of our research.
Research Lines
• Molecular mechanisms of the innate immune system tolerance to tumours in several clinical contexts.
• Molecular mechanisms of endotoxin tolerance in several clinical contexts: respiratory diseases (OSA and cystic fibrosis), acute coronary syndrome, sepsis and septic shock and leukaemias.
• Role of the innate immune system in metastasis.
• Myeloid cell polarization and atherogenesis.
• Role of some mediators of the innate immune system in cardiovascular diseases.