Ovarian carcinoma is the most significant cause of gynaecological cancer-related mortality in Western societies.

However, classical parameters are imperfect predictors of outcome for ovarian carcinoma, which may be due to the molecular genetic events underlying the complexity of ovarian neoplasms and the fact that they are poorly understood.

Precise prognostic factors based on gene expression may identify patients who are more likely to die of the disease despite their response to standard treatment.

Angiogenesis is a complex and highly regulated process that consists of the development of new vessels originating from pre-existing ones. In ovarian cancer, increased angiogenesis is associated with rapid recurrence and decreased survival. The main goal of this subline, therefore, is to identify angiogenesis-related gene expression profiles with prognostic and predictive value in patients with advanced

ovarian carcinoma.

Subline breast cancer

c-Src is overexpressed and/or hyper-activated in breast carcinoma tissue of human biopsies. In xenografts of human breast cancer cell lines, the relevance of Src in mammary tumorigenesis and in bone metastasis has been demonstrated.
Our studies on genetically modified human breast cancer cells in culture, in xenograft and in genetically modified mice may establish the relevance of the scaffold SFKs
function in breast cancer. In addition, our work may lead to the development of new prognosis and diagnosis tools and therapeutic regimens to improve breast cancer treatment.