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Composition
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Name
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Position
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Institution
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Eduardo Manuel López Collazo
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Investigador. Jefe de Laboratorio
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Hospital Universitario La Paz
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Susana Alemany de La Peña
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Investigador. Jefe de Laboratorio
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IIB Alberto Sols. CSIC-UAM
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Lisardo Boscá Gomar
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Investigador. Jefe de Laboratorio
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IIB Alberto Sols. CSIC-UAM
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Antonio Castrillo Viguera
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Investigador. Jefe de Laboratorio
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IIB Alberto Sols. CSIC-UAM
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Irene Fernández Ruiz
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Investigadora Predoctoral
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Hospital Universitario La Paz
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María Susana Guerra García
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Investigadora Postdoctoral
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Universidad Autónoma de Madrid
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Teresa Jurado Camino
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Investigadora Predoctoral
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Hospital Universitario La Paz
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Paloma Martín Sanz
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Investigador. Jefe de Laboratorio
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IIB Alberto Sols. CSIC-UAM
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María Fernández Velasco
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Investigadora Posdoctoral
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IIB. Alberto Sols. CSIC-UAM
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Summary
This group focuses on the study of the reprogramming of the innate immune response in the context of inflammatory diseases (e.g., sepsis, cystic fibrosis, acute coronary
syndrome, lung cancer) using the description of the various molecular mechanisms that underlie the reprogramming of monocytes/macrophages during refractory states.
The innate immune response is activated in various clinical contexts that can be modelled in vitro. The initial reaction of the Innate Immune System is marked by an
inflammatory response that is similar in different contexts.
However, after the initial response, a “deviation” is produced towards an “alternative” response that may, in many cases, lead to refractory states such as endotoxin and tumour tolerance. These refractory states may have undesirable clinical consequences and their study is the objective of our research.
Lines of research
• Molecular mechanisms of endotoxin tolerance in several clinical contexts: respiratory diseases (COPD and cystic fibrosis), acute coronary syndrome, sepsis and septic shock.
• Role of microRNAs in the activation of states refractory to endotoxins and tumours.
• Role of TREM-1 as a marker of lung diseases.
• Molecular mechanisms of the innate immune system tolerance to tumours.
• Role of IRAK-M pseudokinase and TREM-1 receptor in endotoxin tolerance in various clinical contexts.
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